Endocrine Abstracts

Background: Optimal management of hypothyroidism prior to and after conception is associated with improved pregnancy outcomes. Compliance with existing management guidelines in Australia and New Zealand is unknown.Methods: A validated electronic survey was distributed to endocrinologists, obstetricians and general practitioners via their specialty professional bodies and results were analysed.Results: There were 394 survey responde...

Rituximab (RTX) is a monoclonal antibody which binds CD20 antigen and induces B cell depletion. It is not known if its therapeutic effect in autoimmune diseases is mediated by modifications of the humoral immune response, namely the antibody production. Aim of the present study was to evaluate the effect of RTX on serum TSH-receptor antibodies, both binding (TBII) and stimulating (TSAb) and on serum antibodies against three orbital antigens, calsequestrin, XIII collagen and th...